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Potentiation of the insulinotropic and hypoglycemic action of gliquidone by succinic acid esters

par García-Martínez, Juan A.;Villanueva-Peñacarrillo, María Luisa;Valverde, Isabel;Björkling, Fredrik;Malaisse, Willy
Référence European journal of pharmacology, 325, 1, page (65-68)
Publication Publié, 1997-04

Article révisé par les pairs

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Résumé :

The monoethyl, monopropyl and monoisopropyl esters of succinic acid, administered intravenously at the dose of 2 μmol/g body weight, were found to increase the insulinotropic action of gliquidone (0.2 nmol/g body weight) in anaesthetized rats. The monoisopropyl ester of succinic acid also doubled the hypoglycemic action of gliquidone. These findings indicate that it is possible to design esters of succinic acid that are devoid of the risk of generating methanol by intracellular hydrolysis, and yet susceptible to increase both the insulinotropic and hypoglycemic responses to antidiabetic agents.