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Anoxia and glucose-sensitive 86Rb outflow from rat portal vein.

par Antoine, Marie-Hélène ;Herchuelz, André ;Lebrun, Philippe
Référence Pharmacology, 44, 2, page (101-106)
Publication Publié, 1992

Article révisé par les pairs

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Résumé :

Exposure of rat portal veins to an N2-gassed buffer markedly increased 86Rb outflow. Moreover, glucose caused a pronounced reduction in 86Rb outflow from portal veins perfused with an N2-gassed buffer. Pinacidil, cromakalim and diazoxide provoked a sustained increase in 86Rb outflow. The stimulatory effect of pinacidil was not impaired in the absence of extracellular Ca2+ but was completely abolished by glibenclamide. These observations are compatible with the involvement of a metabolic process in the control of the K+ permeability, namely with the existence in rat portal veins of ATP-sensitive K+ channels.