Titre :
  • Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
Auteur : Srinivasan, Supriya ; Lubrano-Berthelier, Cecile ; Govaerts, Cédric ; Picard, Franck ; Santiago, Pamela ; Conklin, Bruce R ; Vaisse, Christian
Informations sur la publication : The Journal of clinical investigation, 114, 8, (page 1158-1164)
Statut de publication : Publié, 2004-10
Sujet CREF : Sciences bio-médicales et agricoles
Biochimie
Biologie
Biologie cellulaire
Biologie moléculaire
Biophysique
Sciences biomédicales
Sciences de la matière vivante
Mots-clés MeSH : Agouti-Related Protein
Amino Acid Sequence
Animals
Cell Line
Cyclic AMP -- metabolism
Drug Design
Eating
Energy Metabolism
Homeostasis
Humans
Intercellular Signaling Peptides and Proteins
Ligands
Mice
Molecular Sequence Data
Obesity -- genetics
Obesity -- metabolism
Point Mutation
Protein Structure, Secondary
Proteins -- metabolism
Receptor, Melanocortin, Type 4 -- chemistry
Receptor, Melanocortin, Type 4 -- genetics
Receptor, Melanocortin, Type 4 -- metabolism
Second Messenger Systems -- physiology
Transcriptional Activation
alpha-MSH -- metabolism
Note : Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9738 
info:doi/10.1172/JCI21927
info:pmid/15489963
info:pmcid/PMC522250