• Citer

Possible misinterpretations of radioimmunoassay results of endocrine tissues containing peptides in the micromolar range.

par Lotstra, Françoise ;Vanderhaeghen, Jean-Jacques
Référence Medical biology, 62, 1, page (59-63)
Publication Publié, 1984

Article révisé par les pairs

• Détails
• Contenu

Résumé :

This paper describes the possible inhibition of labelled peptidic antigen antibody bindings of high affinity (affinity constant above 10(11) l/mol) by structurally non-related synthetic peptides according to their primary aminoacid sequence at concentrations of only 10(-6) mol/l i.e. approximatively 10(-3) g/l, in two radioimmunoassays. Such concentrations of peptides are present in 10% weight/volume suspension of various neuroendocrine and endocrine fresh tissues and may therefore be responsible for false positive results.