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No evidence of antipsychotic effect of caerulein in schizophrenic patients free of neuroleptics: a double-blind cross-over study.

par Lotstra, Françoise ;Verbanck, Paul ;Mendlewicz, Julien ;Vanderhaeghen, Jean-Jacques
Référence Biological psychiatry, 19, 6, page (877-882)
Publication Publié, 1984-06

Article révisé par les pairs

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Résumé :

Because of the relatively small number of patients, caution is required in the interpretation of the data; nevertheless, preliminary double-blind cross-over study does not indicate that caerulein exerts antipsychotic action on schizophrenic patients free from neuroleptics. Because schizophrenia is an heterogeneous disorder, a differential response to caerulein in certain subtypes (particularly in acute cases) cannot be excluded at the present time. Further work must be completed on larger samples with other treatment conditions, such as CCK8-S analogs with improved brain uptake, and controlled trials (in comparison to neuroleptics) in order to investigate the possible effect of these peptides in schizophrenia or other disorders.