Titre :
  • Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients.
Auteur : Bulitta, Jürgen B ; Zhao, Ping ; Arnold, Robert D ; Kessler, Dean R ; Daifuku, Richard ; Pratt, James ; Luciano, Gabriel ; Hanauske, Axel-R ; Gelderblom, Hans ; Awada, Ahmad ; Jusko, William J
Informations sur la publication : Cancer chemotherapy and pharmacology, 63, 6, (page 1035-1048)
Statut de publication : Publié, 2009-05
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : LC-MS/MS
Monte Carlo simulation
Multiple-pool cell lifespan model
Neutrophils/toxicity
Non-hematological malignancies
Paclitaxel
Population pharmacokinetics and pharmacodynamics
Mots-clés MeSH : Antineoplastic Agents, Phytogenic -- administration & dosage
Antineoplastic Agents, Phytogenic -- adverse effects
Antineoplastic Agents, Phytogenic -- blood
Antineoplastic Agents, Phytogenic -- chemistry
Antineoplastic Agents, Phytogenic -- pharmacokinetics
Cell Survival -- drug effects
Chemistry, Pharmaceutical
Chromatography, Liquid
Cross-Over Studies
Female
Humans
Leukocyte Count
Linear Models
Male
Middle Aged
Models, Biological
Neoplasms -- drug therapy
Neutropenia -- chemically induced
Neutrophils -- cytology
Neutrophils -- drug effects
Paclitaxel -- administration & dosage
Paclitaxel -- adverse effects
Paclitaxel -- blood
Paclitaxel -- chemistry
Paclitaxel -- pharmacokinetics
Stem Cells -- cytology
Stem Cells -- drug effects
Structure-Activity Relationship
Tandem Mass Spectrometry
Note : Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0344-5704 
info:doi/10.1007/s00280-008-0828-1
info:pmid/18791717