Titre :
  • Ac His1 [D-Phe2, K15, R16, L27] VIP (3-7)/GRF (8-27)--a VPAC1 receptor antagonist--is an inverse agonist on two constitutively active truncated VPAC1 receptors.
Auteur : Vertongen, Pascale ; Langlet, Christelle ; Langer, Ingrid ; Gaspard, Nathalie ; Robberecht, Patrick
Informations sur la publication : Peptides, 25, 11, (page 1943-1949)
Statut de publication : Publié, 2004-11
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés : Chinese hamster ovary cells
CHO
concentration of agonist required for half maximal response
Constitutive activity
EC
EC50
extracellular loops
GRF
Inverse agonism
Truncated recombinant receptors
VPAC1 receptor
Mots-clés MeSH : Adenylate Cyclase -- metabolism
Amino Acid Sequence
Animals
Binding, Competitive
CHO Cells
Clone Cells
Cricetinae
Cricetulus
Humans
Inhibitory Concentration 50
Iodine Radioisotopes -- diagnostic use
Ligands
Molecular Sequence Data
Peptides, Cyclic -- pharmacology
Protein Conformation
Receptors, Vasoactive Intestinal Peptide -- chemistry
Receptors, Vasoactive Intestinal Peptide -- metabolism
Receptors, Vasoactive Intestinal Polypeptide, Type I
Recombinant Proteins -- chemistry
Recombinant Proteins -- metabolism
Transfection
Vasoactive Intestinal Peptide -- chemical synthesis
Vasoactive Intestinal Peptide -- chemistry
Vasoactive Intestinal Peptide -- isolation & purification
Vasoactive Intestinal Peptide -- pharmacology
Note : Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0196-9781 
info:doi/10.1016/j.peptides.2004.06.001
info:pii/S0196978104002530
info:pmid/15501526