Titre :
  • Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
Auteur : Cnop, Miriam ; Ladrière, Laurence ; Hekerman, Paul ; Ortis, Fernanda ; Dogusan, Zeynep ; Flamez, Daisy ; Boyce, M. ; Yuan, J. ; Eizirik, Decio L. ; Cardozo, Alessandra K
Informations sur la publication : The Journal of biological chemistry, 282, 6, (page 3989-3997)
Statut de publication : Publié, 2007
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Apoptosis -- drug effects
Apoptosis -- physiology
Cells, Cultured
Cinnamates -- pharmacology
Endoplasmic Reticulum -- drug effects
Endoplasmic Reticulum -- metabolism
Endoplasmic Reticulum -- pathology
Eukaryotic Initiation Factor-2 -- antagonists & inhibitors
Eukaryotic Initiation Factor-2 -- metabolism
Fatty Acids, Nonesterified -- physiology
Insulin-Secreting Cells -- drug effects
Insulin-Secreting Cells -- metabolism
Insulin-Secreting Cells -- pathology
Male
Oxidative Stress -- drug effects
Oxidative Stress -- physiology
Phosphorylation -- drug effects
Rats
Rats, Wistar
Thiourea -- analogs & derivatives
Thiourea -- pharmacology
Note : Journal Article
Research Support, Non-U.S. Gov't
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9258 
info:doi/10.1074/jbc.M607627200
info:pii/M607627200
info:pmid/17158450