Titre :
  • The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity.
Auteur : Wali, Jibran JA ; Rondas, Dieter ; McKenzie, M D MD ; Zhao, Y Y ; Elkerbout, L L ; Fynch, S S ; Gurzov, Esteban Nicolas ; Akira, S S ; Mathieu, Chantal C ; Kay, T W H TW ; Overbergh, Lut L. ; Strasser, Andreas A ; Thomas, Helen H.E.
Informations sur la publication : Cell death & disease, 5, (page e1124)
Statut de publication : Publié, 2014-03
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Animals
Antioxidants -- pharmacology
Apoptosis -- drug effects
Apoptosis Regulatory Proteins -- deficiency -- genetics -- metabolism
Bcl-2-Like Protein 11
Cell Line
Diabetes Mellitus, Type 2 -- metabolism -- pathology
Endoplasmic Reticulum -- drug effects -- metabolism -- pathology
Endoplasmic Reticulum Stress -- drug effects
Glucose -- metabolism
Humans
Insulin-Secreting Cells -- metabolism -- pathology
Islets of Langerhans -- drug effects -- metabolism -- pathology
Membrane Proteins -- deficiency -- genetics -- metabolism
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Mitochondria -- drug effects -- metabolism -- pathology
Oxidants -- pharmacology
Oxidative Stress -- drug effects
Proto-Oncogene Proteins -- deficiency -- genetics -- metabolism
RNA, Messenger -- metabolism
Ribose -- metabolism
Tissue Culture Techniques
Transcription Factor CHOP -- deficiency -- genetics
Tumor Suppressor Proteins -- deficiency -- genetics -- metabolism
Langue :
  • Anglais
Identificateurs : urn:issn:E230326 
info:doi/10.1038/cddis.2014.88
info:pii/cddis201488
info:pmid/24625983
info:pmcid/PMC3973197