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European combined analysis of the CTG18.1 and the ERDA1 CAG/CTG repeats in bipolar disorder

par Del-Favero, Jurgen;Blackwood, Douglas Hr;Kruse, Torben;Mendlewicz, Julien ;Schalling, Martin;Van Broeckhoven, Christine;Van Gestel, Sofie;Børglum, Anders Dupont;Muir, Walter;Ewald, Henrik;Mors, Ole;Ivezić, Sladana Štrkalj;Oruč, Lilijana;Adolfsson, Rolf
Référence European journal of human genetics, 10, 4, page (276-280)
Publication Publié, 2002

Article révisé par les pairs

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Résumé :

Several groups have reported association between large CAG/CTG repeats in the genome and BP disorder using the Repeat Expansion Detection (RED) method. Molecular interpretation studies demonstrated that around 90% of the large CAG/CTG repeats detected by RED can by explained by repeat size at either the CTG18.1 or ERDA-1 locus. In this study we report the findings on a large European BP case-control sample analysed for these two frequently expanded repeats. The frequency of expanded alleles (> 40 repeats) at the CTG18.1 locus was significantly higher in the subgroup of patients with a more severe phenotype BPI and a positive first degree family history than in a group of matched controls (9% vs 5%). No difference in ERDA-1 expansion frequency was seen between BP cases and matched controls. We conclude that the ERDA-1 locus is not related to the BP phenotype while expanded alleles at the CTG18.1 locus cannot be excluded as a vulnerability factor for BP disorder.