par Gerard, Catherine 
;Bruyns, Catherine ;Goldman, Michel ;Velu, Thierry
Référence MS. Médecine sciences, 11, 10, page (1431-1435)
Publication Publié, 1995
;Bruyns, Catherine ;Goldman, Michel ;Velu, Thierry Référence MS. Médecine sciences, 11, 10, page (1431-1435)
Publication Publié, 1995
Article révisé par les pairs
| Résumé : | Tumors developed different ways of escaping immune recognition. The ability to release immunosuppressive factors directed against T lymphocytes may be one mechanism of such escape. Interleukin 10 (IL10) has been proposed to be one of these factors, because of its potent immunosuppressive properties on cell-mediated immune responses. Moreover, if the pattern of cytokine gene expression is analyzed within solid tumors, the IL10 gene is one of the most frequently expressed in many different tumor types. This suggests that the IL10 secretion in a tumor microenvironment may play a role in carcinogenesis by preventing an adequate antitumoral immune response. Contrarily to what was hypothesized, the transfer of the IL10 cDNA and its subsequent expression in mouse melanoma cells result in a loss of their tumorigenicity in syngeneic mice. Moreover, a single vaccination with IL10 producing melanoma cells is able to protect the mice against a subsequent challenge with parental cells. Thus, in this tumor model IL10 seems to be immunostimulatory rather than immunosuppressive, and has a surprising antitumoral activity. It remains to determine if this effect could be generalized to other tumor types and if IL10 is finally a factor favoring the escape of a tumor to the immune system or if it could increase the immunogenicity of a tumor and help its rejection. |
