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Protein structural analysis as a tool for protein design

par Leplae, Raphaël ;Lahm, Armin;Tramontano, Anna
Référence Biopolymers, 37, 6, page (377-382)
Publication Publié, 1995

Article révisé par les pairs

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Résumé :

The analysis of known protein structures is a very valuable and indispensable tool for deciphering the complex rules relating sequence to structure in proteins. On the other hand, the design of novel proteins is certainly the most severe test of our understanding of such rules. In this report we describe our own attempt to develop appropriate tools for the investigation of known protein structure properties and their applications to the design of a novel, all β protein. The success of the design project is a demonstration of the usefulness of careful analysis of the data base of known protein structures.