The Role of Nucleotide Receptors in the Cardiovascular System

Pirotton, Sabine; Desgranges, Claude; Vassort, Guy; Boeynaems, Jean-Marie; Turner, John T.; Weisman, Gary A; Fedan, Jeffrey

doi:doi/10.1007/978-1-4612-1800-5_13

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The Role of Nucleotide Receptors in the Cardiovascular System

par Pirotton, Sabine

;Desgranges, Claude ;Vassort, Guy ;Boeynaems, Jean-Marie

Editeur scientifique Turner, John T.;Weisman, Gary A ;Fedan, Jeffrey
Référence The P2 Nucleotide Receptors, Humana Press, New York, NY, page (319-359)
Publication Publié, 1998

Partie d'ouvrage collectif

Résumé :

The first observation of a biological activity for adenine nucleotides on the cardiovascular system was reported by Drury and Szent-Györgyi in 1929: when administered iv to guinea pigs, adenosine triphosphate (ATP) induced a decrease in heart rate and arterial blood pressure and a dilation of coronary blood vessels. Since that time, multiple effects of nucleotides have been described and much progress has been made in the understanding of their mechanisms of action on different components of the cardiovascular system, including endothelium, smooth muscle cells (SMC), and cardiomyocytes.

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