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The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response.

par Satitsuksanoa, Pattraporn;Kennedy, Malcolm M.W.;Gilis, Dimitri ;Le Mignon, Maxime;Suratannon, Narissara;Wai, Tuck Soh;Wongpiyabovorn, Jongkonnee;Chatchatee, Pantipa;Vangveravong, Mukda;Rerkpattanapipat, Ticha;Sangasapaviliya, Atik;Piboonpocanun, Surapon;Nony, Emmanuel;Ruxrungtham, Kiat;Jacquet, Alain ;Mite Allergy Research Cohort (MARC) study team,
Référence Allergy, 71, 10, page (1425-1434)
Publication Publié, 2016-03

Article révisé par les pairs

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Résumé :

The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response. We investigated the IgE reactivity of recombinant Der p 13 (rDer p 13), its lipid binding activities and its capacity to stimulate airway epithelium cells.