• Citer

An EORTC Gastrointestinal (GI) Group randomized evaluation of the toxicity of sequential high dose methotrexate and 5-fluorouracil combined with adriamycin (FAMTX) vs 5-fluorouracil, adriamycin and mitomycin (FAM) in advanced gastric cancer

par Klein, Hans Otto;Wils, Jaques;Bleiberg, Harry ;Buyse, Marc;Duez, Nicole
Référence Medical Oncology and Tumor Pharmacotherapy, 6, 2, page (171-174)
Publication Publié, 1989

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

Until now advanced gastric cancer has been generally treated with the FAM chemotherapy protocol. Due to the relatively low response rates with this protocol we decided to start a randomized prospective phase II trial comparing the FAM with the FAMTX protocol. The primary aim of our trial was to compare the toxicity in both protocols. The FAMTX protocol has been demonstrated to be fully comparable with the toxicity of the FAM protocol. The trial has been extended to a phase III study. With respect to response rates and survival times it is too early for evaluation. © 1989, Humana Press Inc.. All rights reserved.