par Kesse-Guyot, Emmanuelle;Touvier, Mathilde;Henegar, Adina;Czernichow, Sébastien;Galan, Pilar;Hercberg, Serge;Castetbon, Katia 
Référence European journal of clinical nutrition, 65, 8, page (887-894)
Publication Publié, 2011-08
Référence European journal of clinical nutrition, 65, 8, page (887-894)
Publication Publié, 2011-08
Article révisé par les pairs
| Résumé : | BACKGROUND/OBJECTIVES:Nutritional recommendations are widely disseminated, but assessment of their predictive value for risk of chronic diseases and mortality is essential for ensuring their validity. We evaluated, in a large population-based study, the association between the French Programme National Nutrition Santé (PNNS) Guideline Score (GS) (maximum score of 15 points), an a priori-based score, and the incidences of cancer, cardiovascular disease (CVD) and overall mortality.SUBJECTS/METHODS:Subjects included in this analysis (n=5823) were participants in the Supplémentation en Vitamines et Minéraux AntioXydants study, with available data for estimating the PNNS-GS. Hazards ratios (HRs) and 95% confidence intervals (95% CIs) for outcomes (cancer, CVD and death) were estimated across quartiles of PNNS-GS using Cox proportional hazards models.RESULTS:A total of 734 major events were recorded during an average 11.6-year follow-up (maximum 13 years): 423 cancers, 193 ischemic diseases and 118 deaths. In the fully adjusted model, a significant reduction in CVD risk between the first and fourth PNNS-GS quartiles (HR=0.65, 95% CI=0.41, 1.00, P for trend=0.04) was observed. No significant overall association with risk of cancer or death was detected.CONCLUSIONS:These observations support the role of nutritional guidelines in prevention of CVD. |
