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Adaptations of Trypanosoma brucei to the innate immunity proteins TNF-gas and ApoL-1

par Vanwalleghem, Gilles
Président du jury Leo, Oberdan
Promoteur Pays, Etienne
Publication Non publié, 2012-03-06

Thèse de doctorat

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Résumé :

This work allowed the first characterization of the three members of the chloride channel CLC family in T.brucei. The TbCLCs are expressed in the two proliferative stages of the parasite and two of their members appear non-essential. The three TbCLCs act as chloride transporters in X.laevis oocytes and some of their biophysical properties were determined. Furthermore, TbCLC-b appeared to be involved in lysis by the human innate immunity protein apoL-1 A novel function of T.brucei adenylate cyclases was discovered in their ability to suppress expression of the innate immunity protein TNF-α. The suppression of the innate response occurs before the first peak of parasitemia and reduces the host ability to control the parasite.