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Microsatellite instable vs stable colon carcinomas: analysis of tumour heterogeneity, inflammation and angiogenesis.

par De Smedt, L;Lemahieu, J;Palmans, S;Govaere, Olivier;Tousseyn, Thomas;Van Cutsem, Eric;Prenen, Hans;Tejpar, Sabine;Spaepen, M;Matthijs, G;Decaestecker, Christine ;Moles Lopez, Xavier ;Demetter, Pieter ;Salmon, Isabelle ;Sagaert, Xavier
Référence British Journal of Cancer, 113, 3, page (500-9)
Publication Publié, 2015-07-28

Article révisé par les pairs

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Résumé :

Microsatellite instability (MSI) accounts for 15% of all colorectal tumours. Several specific clinicopathologicals (e.g., preference for the proximal colon over the distal colon, improved prognosis and altered response to chemotherapeutics) are described for this subset of tumours. This study aimed to analyse morphological, inflammatory and angiogenic features of MSI vs microsatellite stable (MSS) tumours.