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Inspiratory and expiratory lung pressure-volume curve in healthy males and females

par Noseda, André ;Van Muylem, Alain ;Estenne, Marc ;Yernault, Jean Claude
Référence Clinical Respiratory Physiology, 20, 3, page (245-249)
Publication Publié, 1984

Article révisé par les pairs

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Résumé :

Quasistatic lung inspiratory and expiratory pressure-volume curves were obtained in 58 healthy non-smoking males (mean age ± SD: 42.8 ± 15.1 years; range: 22-70) and 56 healthy nonsmoking females (mean age ±SD: 41.4 ± 15.6 years; range: 21-76). Inspiratory and expiratory lung recoil pressures were measured at fixed percentages of TLC (100, 95, 90, 80, 70, 60 and 50%). In both sexes, inspiratory as well as expiratory lung recoil pressures were found to decrease linearly with aging (p <0.01 for all r values). There was no significant difference between males and females. At and above the 70% TLC level, the slopes of the age-related decreases in lung recoil were similar for the inspiratory and expiratory curves. At the 60% TLC level, the decrease in expiratory lung recoil was significantly (p <0.01) faster than the decrease in inspiratory lung recoil, presumably reflectng the influence of airway opening of the inspiratory pressure in older subjects. The shape of the expiratory PV curve described by the K index of the exponential model was similar in both sexes and changed with aging, K increasing significantly (p <0.01). By contrast, the shape of the inspiratory limb of the PV curve did not vary with aging. Consequently, the shape of the inspiratory PV curve cannot be predicted from the expiratory one and has to be measured directly.