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Transport of cortisol, progesterone and cholesterol across isolated mesentery - Effect of metyrapone

par Couturier, Etienne ;Bruno, Oscar Domingo;Metzger, Patricia ;Leclercq, Raoul ;Copinschi, Georges
Référence The journal of membrane biology, 13, 1, page (89-96)
Publication Publié, 1973-12

Article révisé par les pairs

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Résumé :

Isolated rat mesentery, mounted in a diffusion cell, is used as a model for the study of vascular endothelium permeability characteristics. The passage of tracer molecules is measured in the absence of osmotic or hydrostatic pressure gradients across the mesentery. The permeability coefficient of the membrane for cortisol and progesterone is similar. When bound to transcortin, cortisol crosses mesentery at a significantly slower rate. Metyrapone diatartrate increases by 30% the passage of free and of transcortinbound cortisol, but is without effect on the passage of progesterone or glucose in the same conditions. When the transfer of cholesterol across mesentery is studied, a high percentage of the tracer is trapped by the membrane. © 1973 Springer-Verlag New York Inc.