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Influence of manufacturing parameters on the size characteristics and the release profiles of nifedipine from poly(DL-lactide-co-glycolide) microspheres

par Sansdrap, Pascale ;Moës, A.J.
Référence International journal of pharmaceutics, 98, 1-3, page (157-164)
Publication Publié, 1993

Article révisé par les pairs

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Résumé :

Empty or nifedipine-loaded biodegradable poly(dl-lactide-co-glycolide) microspheres were prepared by the solvent evaporation method. Spherical microparticles of different size distribution were thus obtained. The evolution of the mean diameter and the extent of size distribution as a function of different preparation parameters were studied. The mean particle diameter decreased when the stirring rate, the surface-active agent concentration and the internal phase volume were increased. Microspheres of 12, 18 and 83 μm, with different nifedipine payloads were obtained. The in vitro release of the drug was evaluated under sink and non-sink conditions: the 12 and 18 μm microspheres provide the same linear profile for approx. 400 h. Under non-sink conditions, the 83 μm microspheres exhibit an S-shape release pattern. © 1993.