par Gueuning, Christiane 
;Vermeulen, Claudine ;Graff, Guy
Référence Archives internationales de physiologie et de biochimie, 85, 1, page (67-89)
Publication Publié, 1977
;Vermeulen, Claudine ;Graff, Guy Référence Archives internationales de physiologie et de biochimie, 85, 1, page (67-89)
Publication Publié, 1977
Article révisé par les pairs
| Résumé : | Inorganic phosphate exchanges between plasma and sciatic nerve were measured in the rabbit using a 32PO4 tracer technique. Inorganic phosphate is taken up at the rate of 0.13 μg per hr and per 100 mg fresh weight. Incorporation of plasma radiophosphate is markedly increased into the inorganic acid soluble phosphate fractions of the distal part of the sectioned sciatic nerve. This increase is already significant within 1 hr after surgicial division, spreading at least 3 cm distally within 6 hr. This high level of incorporation persists until the 29th day of degeneration. These results favour the hypothesis that the axonal continuity maintains the metabolic activity of the Schwann cells at an inframaximal level. The authors confirm the rapid decrease in total phospholipid concentration in the nerve undergoing Wallerian degeneration as well as the marked increase in their specific activity. The authors show however that this increase in specific activity is due partly to the increased specific activities of the precursors (organic acid soluble phosphates), partly to the disappearance of a metabolically inert pool (myelin phospholipids). The Schwann cells of the nerve undergoing Wallerian degeneration do not have a more active phospholipid metabolism than their normal counterparts. |
