par Delvigne, Annick ;Vandromme, Jean ;Barlow, Patricia ;Lejeune, Bernard ;Leroy, Fernand
Référence Human reproduction, 6, 7, page (959-962)
Publication Publié, 1991
Article révisé par les pairs
Résumé : Among 599 trials of in-vitro fertilization (IVF) treatment, complicated ovarian hyperstimulation (OHSS) was diagnosed in 14 cases (2.5%) on the basis of heavy abdominal discomfort and echographic findings (ascites, ovarian enlargement with cysts). Among eight hospitalized patients, four presented with a haemoconcentration and/or electrolytic disturbances. OHSS cases were compared with two control groups for a series of criteria: age, aetiology of infertility, total dose of human menopausal gonadotrophin (HMG), day of oocyte collection, oestradiol (E 2) peak level, rate of E 2 increase, number of oocytes, number of embryos transferred and embryonic vitality scores. Comparison with a random group of normal IVF trials showed a significant difference for the following parameters: E 2 peak level and rate of increase, E 2/dose of HMG, E 2/day of egg collection and number of oocytes. When OHSS cases were compared to another control group consisting only of high E 2 responders (peak E 2 > 2700 pg/ml), no significant difference was found for any of the above-mentioned criteria. In view of this lack of predictive power of individual criteria, stepwise discriminant analysis was applied, showing that this method might provide a predictive mathematical function for evaluating the risk of OHSS before human chorionic gonadotrophin (HCG) administration. Such a formula, however, should be validated by a multicentric study in which a greater number of OHSS cases would be tested.

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