par Camus, Marguerite 
;Lejeune, Bernard ;Leroy, Fernand
Référence Biology of reproduction, 20, 5, page (1115-1118)
Publication Publié, 1979
;Lejeune, Bernard ;Leroy, Fernand Référence Biology of reproduction, 20, 5, page (1115-1118)
Publication Publié, 1979
Article révisé par les pairs
| Résumé : | Systemic administration of various doses of actinomycin D to ovariectomized pregnant rats treated with progesterone (P), was unable to induce implantation of 'delayed' blastocysts in a significant number of animals. However, under the same conditions, topical injection of this drug into the parametrium entailed the occurrence of implantation sites into the homolateral uterine horn in 71% of rats. It is concluded that actinomycin D precipitates implantation by acting directly on uterine cells. Intraparametrial injections of α-amanitin or cycloheximide did not elicit significant rates of implantation. |
