Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets.

Wolden-Kirk, H; Overbergh, Lutgart; Gysemans, C; Brusgaard, K; Naamane, Najib; Van Lommel, Leentje; Schuit, F; Eizirik, Decio L.; Christesen, H; Mathieu, C

doi:doi/10.1016/j.jsbmb.2012.10.017

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Unraveling the effects of 1,25OH2D3 on global gene expression in pancreatic islets.

par Wolden-Kirk, H ;Overbergh, Lutgart ;Gysemans, C ;Brusgaard, K ;Naamane, Najib

;Van Lommel, Leentje ;Schuit, F ;Eizirik, Decio L.

;Christesen, H ;Mathieu, C
Référence Journal of steroid biochemistry and molecular biology, 136, page (68-79)
Publication Publié, 2013

Article révisé par les pairs

Résumé :

Vitamin D deficiency has been linked to type 1 and 2 diabetes, whereas supplementation may prevent both diseases. However, the extent of the effects of vitamin D or its metabolites directly on pancreatic islets is still largely unknown. The aim of the present study was to investigate how active vitamin D, 1,25(OH)2D3, affects beta cells directly by establishing its effects on global gene expression in healthy murine islets.

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