Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial.

Mercier, Jean-Christophe; Hummler, Helmut; Durrmeyer, Xavier; Sanchez-Luna, Manuel; Carnielli, Virgilio; Field, David; Greenough, Anne; Van Overmeire, Bart; Jonsson, Baldvin; Hallman, Mikko; Baldassarre, James; EUNO Study Group

doi:doi/10.1016/S0140-6736(10)60664-2

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Inhaled nitric oxide for prevention of bronchopulmonary dysplasia in premature babies (EUNO): a randomised controlled trial.

par Mercier, Jean-Christophe ;Hummler, Helmut ;Durrmeyer, Xavier ;Sanchez-Luna, Manuel ;Carnielli, Virgilio ;Field, David ;Greenough, Anne ;Van Overmeire, Bart

;Jonsson, Baldvin ;Hallman, Mikko ;Baldassarre, James ;EUNO Study Group,
Référence Lancet, 376, 9738, page (346-354)
Publication Publié, 2010-07

Article révisé par les pairs

Résumé :

In animal models, inhaled nitric oxide improved gas exchange and lung structural development, but its use in premature infants at risk of developing bronchopulmonary dysplasia remains controversial. We therefore tested the hypothesis that inhaled nitric oxide at a low concentration, started early and maintained for an extended period in babies with mild respiratory failure, might reduce the incidence of bronchopulmonary dysplasia.

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