Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients.

Harradine, Kelly A; Ridd, Katie; Saunier, Elise F; Clermont, Frédéric; Perez-Losada, Jesus; Moore, Dan H; Epstein, Ervin H; Bastian, Boris C; Akhurst, Rosemary J

doi:doi/10.1158/1078-0432.CCR-08-3286

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Elevated cutaneous Smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients.

par Harradine, Kelly A ;Ridd, Katie ;Saunier, Elise F ;Clermont, Frédéric

;Perez-Losada, Jesus ;Moore, Dan H ;Epstein, Ervin H ;Bastian, Boris C ;Akhurst, Rosemary J
Référence Clinical cancer research, 15, 16, page (5101-5107)
Publication Publié, 2009-08

Article révisé par les pairs

Résumé :

Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ transplantation. Preclinical studies suggest that ARD treatment increases transforming growth factor-beta1 (TGF-beta1) levels, which contribute to enhanced tumor susceptibility independent of the immunosuppressive effects of ARDs. This study investigates whether TGF-beta signaling is elevated in transplant patients.

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