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Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes.

par De Preter, Katleen;Vandesompele, Jo;Heimann, Pierre ;Yigit, Nurten;Beckman, Siv;Schramm, Alexander;Eggert, Angelika;Stallings, Raymond L;Benoît, Yves;Renard, Marleen;De Paepe, Anne;Laureys, G;Påhlman, Sven;Speleman, Frank
Référence Genome biology, 7, 9, page (R84)
Publication Publié, 2006

Article révisé par les pairs

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Résumé :

Neuroblastoma tumor cells are assumed to originate from primitive neuroblasts giving rise to the sympathetic nervous system. Because these precursor cells are not detectable in postnatal life, their transcription profile has remained inaccessible for comparative data mining strategies in neuroblastoma. This study provides the first genome-wide mRNA expression profile of these human fetal sympathetic neuroblasts. To this purpose, small islets of normal neuroblasts were isolated by laser microdissection from human fetal adrenal glands.