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Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells.

par Delers, Anne;Szpirer, Josiane ;Szpirer, Claude ;Saggioro, Daniela
Référence Molecular and cellular biology, 4, 4, page (809-812)
Publication Publié, 1984-04

Article révisé par les pairs

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Résumé :

Rat hepatoma cells that do not synthesize the hepatic enzyme ornithine carbamoyl transferase spontaneously give rise to producing cells at a low frequency. Reexpression of this differentiation trait is strongly increased by 5-azacytidine treatment, suggesting that hypermethylation plays a critical role in the impaired expression of the ornithine carbamoyl transferase gene in hepatoma cells.