par Fojt, Lukáš;Vetterl, Vladimír;Doneux, Thomas 
Référence Bioelectrochemistry, 75, 2, page (89-94)
Publication Publié, 2009
Référence Bioelectrochemistry, 75, 2, page (89-94)
Publication Publié, 2009
Article révisé par les pairs
| Résumé : | Purine and pyrimidine derivatives occurring in nucleic acids posses an extraordinary high ability of self-association at the electrode surface and can form there by a two-dimensional (2D) condensation a monomolecular compact film (self-assembled monolayer-SAM). The effects of methyl substituent on the 2D condensation were studied using the 5-methylcytosine molecule which is involved in gene silencing and has a great biological impact. At acid pHs, 5-methylcytosine forms at the mercury electrode a physisorbed self-assembled 2D layer at potentials close to the potential of electrocapillary maximum. From the temperature dependence of the electrode double layer capacitance, the standard Gibbs energy of adsorption (ΔGm = - 12.7 kJ mol- 1), lateral interaction coefficient of the Frumkin adsorption isotherm (ac = 2.05) and area occupied by one molecule (A = 1.31 nm2) in the 2D layer were determined. Measurements performed on a single-crystal Au(111) surface show that the 2D condensation can take place on other substrates as well. © 2009 Elsevier B.V. All rights reserved. |
