par Dupont, Geneviève 
Référence The American journal of physiology, 275, page (317-322)
Publication Publié, 1998
Référence The American journal of physiology, 275, page (317-322)
Publication Publié, 1998
Article révisé par les pairs
| Résumé : | Spiral waves of intracellular Ca2+ have often been observed in Xenopus oocytes. Such waves can be accounted for by most realistic models for Ca2+ oscillations taking diffusion of cytosolic Ca2+ into account, but their initiation requires rather demanding and unphysiological initial conditions. Here, it is shown by means of numerical simulations that these spiral Ca2+ waves naturally arise if the cytoplasm is assumed to be heterogeneous both at the level of the synthesis and metabolism of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and at the level of the distribution of the Ins(1,4,5)P3 receptors. In such conditions, a spiral can be initiated in the simulations after an increase in Ins(1,4,5)P3 concentration, with the direction of rotation being determined by the position of the region of high receptor density with respect to the locus of Ins(1,4,5)P3 production. |
