par De Vriese, Carine 
;Perret, Jason ;Delporte, Christine
Référence Appetite and nutritional assessment, Ellsworth S.J. and Schuster R.C., New York, USA, page (1-48)
Publication Publié, 2009
;Perret, Jason ;Delporte, Christine Référence Appetite and nutritional assessment, Ellsworth S.J. and Schuster R.C., New York, USA, page (1-48)
Publication Publié, 2009
Partie d'ouvrage collectif
| Résumé : | Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor. Ghrelin is a peptide of 28 amino acids possessing an uncommon octanoyl moiety on the serine in position 3, which is crucial for its biological activity. Ghrelin is predominantly produced and secreted into the blood stream by the endocrine X/A like cells of the stomach mucosa. Besides, it is also expressed in other tissues like duodenum, jejunum, ileum, colon, lung, heart, pancreas, kidney, testis, pituitary and hypothalamus. Some of the major biological actions of ghrelin are the secretion of growth hormone, the stimulation of appetite and food intake, the regulation of gastric motility and acid secretion and the modulation of the endocrine and exocrine pancreatic functions. Ghrelin is an orexigenic peptide involved in the short-term regulation of appetite and food intake. The plasma ghrelin levels increase before meal and decrease strongly during the postprandial phase. Long-term body weight is also regulated by ghrelin, since it induces adiposity. The purpose of this chapter is to provide updated information on ghrelin, the role of ghrelin in the control of appetite, as well as the potential clinical applications of ghrelin agonists and antagonists in certain physiopathological conditions. © 2011 by Nova Science Publishers, Inc. All rights reserved. |
