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Synthesis, characterization, X-ray crystal structure and in vitro antitumour activity of bis(1,2-dicarba-closododecaborane-9-carboxylato)di-n-butyltin

par Bregadze, V I;Glazun, S A;Petrovskii, P.V.;Starikova, Eugeniya;Rochev, V.Ya.;Dalil, Hassan ;Biesemans, Monique;Willem, Rudolph ;Gielen, Marcel ;De Vos, Danièle
Référence Applied organometallic chemistry, 17, 6-7, page (453-457)
Publication Publié, 2003-07

Article révisé par les pairs

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Résumé :

The 1 : 2 condensation of dibutyltin(IV) oxide with 1,2-carborane-9-carboxylic acid resulted in bis(1,2-dicarba-closo-dodecaborane-9-carboxylato)di-n-butyltin (1), the first carborane-based organotin compound where the carborane cage is linked to the carboxylic moiety via a boron atom. The structure of 1, characterized by 1H, 11B, 13C, 119Sn NMR spectroscopy and X-ray diffraction, was shown to correspond to bis(1,2-dicarba-closo-dodecaborane-9-carboxylato)di-n-butyltin. Compound 1 was screened in vitro against seven tumour cell lines of human origin and was found to be significantly more active than 5-fluorouracil, cis-platin and carboplatin but less active than methotrexate and doxorubicin. Copyright © 2003 John Wiley & Sons, Ltd.