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Correlations between cascade impactor analysis and laser diffraction techniques for the determination of the particle size of aerosolised powder formulations

par Pilcer, Gabrielle ;Vanderbist, Francis ;Amighi, Karim
Référence International journal of pharmaceutics, 358, 1-2, page (75-81)
Publication Publié, 2008-06

Article révisé par les pairs

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Résumé :

The purpose of the study was to examine the suitability of the Spraytec® laser diffraction technique for measuring the size distribution of aerosol particles generated from dry powder inhalators. A range of formulations with different dispersion properties were produced by spray-drying. The percentage of particles below 5.0 μm of these formulations was measured by laser diffraction (Mastersizer® 2000 and Spraytec®) and inertial impaction (MsLI and NGI) using various inhaler devices and at different flow rates between 30 and 100 l/min. Linear relationships and correlations (R2 > 0.9) existed between the results obtained from, on one hand, the Mastersizer® 2000 and the Spraytec®, and, on the other hand, the MsLI and the Spraytec® regardless of flow rates and inhaler devices. The Spraytec® could be a reliable technique for the development, evaluation and quality control of dry powder aerosol formulations. © 2008 Elsevier B.V. All rights reserved.