• Citer

A unifying model of current concepts and data on adenylate cyclase activation by β-adrenergic agonists

par Swillens, Stéphane ;Dumont, Jacques Emile
Référence Life sciences, 27, 12, page (1013-1028)
Publication Publié, 1980

Article révisé par les pairs

• Accès en ligne
• Détails
• Contenu
• Statistiques

Résumé :

The approach used for the elaboration of the adenylate cyclase system takes into account two types of experimental data: the data of the first type, showing the existence of the different biochemical entities and their possible mutual interaction; the data of the second type describing the behaviour of the whole system as a response to different experimental conditions. The approach the authors are dealing with has been applied to the study of the adenylate cyclase activation by β-adrenergic agonists. The first part of the paper involves a rapid review of the key experimental observation of the first type and the elaboration of the model. The proposed model must be considered as the combination of different submodels : some of them have been proposed elsewhere, the others are original and account for new aspects. The second part of the paper is presented as a set of answers to different questions which have been often raised in relation to the observation of the second type. Finally the third part of the paper is dealing with the prediction of theoretical simulations of the model and with a critical comparison between this model and other integrated concepts by others.