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Modulation of the reninangiotensinaldosterone system in sepsis: A new therapeutic approach?

par Salgado, Diamantino ;Rocco, Jos Rodolfo;Silva, Eliézer;Vincent, Jean Louis
Référence Expert opinion on therapeutic targets, 14, 1, page (11-20)
Publication Publié, 2010-01

Article révisé par les pairs

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Résumé :

Severe sepsis is characterized by relative hypotension associated with a high cardiac output, peripheral vasodilation, and organ dysfunction. The renin-angiotensin-aldosterone system (RAAS) is primarily activated to increase blood pressure, but recently potential pro-inflammatory effects of angiotensin II have attracted interest because of the reported association between angiotensin II levels and organ failure and mortality in sepsis. RAAS antagonists could represent a new therapeutic option in this setting.