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Evidence of a thromboxane A2-Ca2+ complex: a conformational approach.

par Brasseur, Robert ;Ruysschaert, Jean Marie
Référence Research communications in chemical pathology and pharmacology, 46, 2, page (175-185)
Publication Publié, 1984-11

Article révisé par les pairs

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Résumé :

Thromboxane A2 has been proposed as an ionophore capable to transport calcium from the platelet dense tubular system to the cytoplasm to activate the contractile proteins. However the half-life (30 sec.) of this compound limits considerably the experimental approach. The conformational analysis is proposed here as a possible way to identify such transient conformations. We bring evidence of the existence of two Ca2+-thromboxane A2 isomeric complexes: one structure responsible for the complexation-decomplexation process at the interface and one lipophilic structure able to cross the lipid membrane.