par Sener, Abdullah 
;Herberg, L.;Malaisse, Willy
Référence FEBS letters, 316, 3, page (224-227)
Publication Publié, 1993
;Herberg, L.;Malaisse, Willy Référence FEBS letters, 316, 3, page (224-227)
Publication Publié, 1993
Article révisé par les pairs
| Résumé : | The mitochondrial enzyme FAD-linked glycerophosphate dehydrogenase plays a key role in the glucose-sensing device of the insulin-producing pancreatic B-cell. Its activity was found to be decreased in islet, but not liver, homogenates of BL/ Ks-db/db mice, in which diabetes mellitus represents an inherited disease. The decreased activity of FAD-linked glycerophosphate dehydrogenase contrasted with a normal activity of glutamate dehydrogenase and 2-ketoglutarate dehydrogenase in the islets of db/db mice. It is proposed that a site-specific defect of FAD-linked glycerophosphate dehydrogenase in the pancreatic B-cell might represent a far-from-uncommon causal or contributing factor in the pathogenesis of non-insulin-dependent diabetes mellitus. |
