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Molecular models of human P-glycoprotein in two different catalytic states.

par Becker, Jean-Paul ;Depret, Grégoire;Van Bambeke, Françoise;Tulkens, Paul M.;Prévost, Martine
Référence BMC structural biology, 9, page (3)
Publication Publié, 2009

Article révisé par les pairs

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Résumé :

P-glycoprotein belongs to the family of ATP-binding cassette proteins which hydrolyze ATP to catalyse the translocation of their substrates through membranes. This protein extrudes a large range of components out of cells, especially therapeutic agents causing a phenomenon known as multidrug resistance. Because of its clinical interest, its activity and transport function have been largely characterized by various biochemical studies. In the absence of a high-resolution structure of P-glycoprotein, homology modeling is a useful tool to help interpretation of experimental data and potentially guide experimental studies.