par Herchuelz, André 
;Gangji, D;Derenne, F;Jeanniot, J P;Douchamps, J
Référence British journal of clinical pharmacology, 31, 1, page (73-76)
Publication Publié, 1991-01
;Gangji, D;Derenne, F;Jeanniot, J P;Douchamps, JRéférence British journal of clinical pharmacology, 31, 1, page (73-76)
Publication Publié, 1991-01
Article révisé par les pairs
| Résumé : | 1. Almitrine bismesylate displays wide inter-subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine. |
