par Hager, D;Pipeleers, Daniel;Herchuelz, André ;Malaisse, Willy
Référence Acta medica Scandinavica. Supplementum, 542, page (159-164)
Publication Publié, 1972
Article révisé par les pairs
Résumé : Abstract. Glucose and mannose stimulate insulin release, insulin biosynthesis and calcium uptake in rat isolated islets. Their insulinotropic action is enhanced by caffeine or theophylline. Ribose and xylitol might also exert a minor insulinotropic action. Fructose and galactose do not stimulate insulin release whether in the presence or absence of methylxanthine (10.0 mM), and do not affect insulin biosynthesis or calcium uptake by the islets. These converging findings on several parameters of islet function support the concept that the insulinotropic effect of sugars is dependent on their intracellular metabolism, or possibly on the activation of a highly‐selective glucoreceptor. 1972 Association for the Publication of the Journal of Internal Medicine