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Kinetics of classes and sub-classes of total immunoglobulins and specific antibodies to Schistosoma mansoni during murine infection.

par Bout, D;Rousseaux, R;Carlier, Yves ;Capron, André
Référence Parasitology, 80, 2, page (247-256)
Publication Publié, 1980-04

Article révisé par les pairs

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Résumé :

During the course of Schistosoma mansoni murine infection there is a dramatic increase of some immunoglobulins and S. mansoni-specific antibodies. The most substantial response is initiated after 40 days of infection and results in a prolonged increase of total IgG1, IgM and IgA. The maximum increase is respectively 26, 14 and 3-fold the basic immunoglobulin level in control mice. Some anti-S. mansoni classes and sub-classes were studied by an original radio-immunoadsorbent test. Anti-S. mansoni IgG1 and IgM antibodies appear and increase at the same time as that of total IgG1 and IgM. Anti-S. mansoni IgA antibodies appear later (80th day) and correspond to a second peak of total IgA.