par Askenasi, Robert ;Linkowski, Paul ;Leeman, Marc
Référence La Nouvelle presse médicale, 10, 42, page (3481-3482)
Publication Publié, 1981-11
Article révisé par les pairs
Résumé : Lithium intoxication may present as seizures, which have been observed when plasma lithium concentrations were decreasing. The neurotoxic effect of lithium could be due to a rise in intra-/extra-cellular lithium ratio. Intracellular retention of lithium reflected in rapid fall of plasma concentrations during treatment would modify cell membrane properties and increase neuronal excitability. Such a mechanism would explain the occurrence of seizures despite therapeutic plasma lithium concentrations.