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delta-9-Tetrahydrocannabinol regulates gene expression of the growth factor pleiotrophin in the forebrain.

par Mailleux, Pierre ;Preud'homme, Xavier A;Albala, N;Vanderwinden, Jean-Marie ;Vanderhaeghen, Jean-Jacques
Référence Neuroscience letters, 175, 1-2, page (25-27)
Publication Publié, 1994-07

Article révisé par les pairs

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Résumé :

delta-9-Tetrahydrocannabinol (THC) is a major psychoactive component of cannabis. We here studied, by quantitative in situ hybridization at the macroscopic level, the possible modulatory effects of acute THC (5 mg/kg/i.p.) on gene expression of the growth factor pleiotrophin (PTN) in the adult rat forebrain. We found, 30 min after a single injection of THC, a significant increase of PTN mRNA concentrations in the cingulate cortex (38%), fronto-parietal cortex (31%) and caudate-putamen (27%). In conclusion, this is the first report on THC regulation of growth factor gene expression in the brain.