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Chagas' disease: decreased resistance to Trypanosoma cruzi acquired infection in offspring of infected mice.

par Carlier, Yves ;Rivera, M. T.;Truyens, Carine ;Ontivero, M;Flament, Julie ;Van Marck, Eric;De Maertelaer, Viviane
Référence The American journal of tropical medicine and hygiene, 46, 2, page (116-122)
Publication Publié, 1992-02

Article révisé par les pairs

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Résumé :

The course of Trypanosoma cruzi infection was studied in an experimental model, using the offspring of mice that were chronically infected with T. cruzi. When infected two months after birth, a higher mortality rate in heavily parasitized mice occurred in these offspring than in controls born to uninfected mothers. The harmful maternal influence reached a maximum when offspring were exposed both to prenatal (placental) and postnatal (lactating) influences. It was a reversible phenomenon that led to a T. cruzi-specific failure of the offspring to control the acute phase of the infection. Such features are suggestive of a maternally-induced impairment of the immune response of the offspring.