Neurofibrillary tangles and the neuronal cytoskeleton.

Anderton, Brian; Brion, Jean Pierre; Flament Durand, Jacqueline; Haugh, M; Kahn, J.E.; Miller, C.C.J.; Probst, A; Ulrich, J

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Neurofibrillary tangles and the neuronal cytoskeleton.

par Anderton, Brian ;Brion, Jean Pierre

;Flament Durand, Jacqueline

;Haugh, M ;Kahn, J.E.;Miller, C.C.J.;Probst, A ;Ulrich, J
Référence Journal of neural transmission. Supplementum, 24, page (191-196)
Publication Publié, 1987

Article révisé par les pairs

Résumé :

Antibodies to neurofilaments and the microtubule-associated protein, tau, have been used with anti-paired helical filament (PHF) serum to study Alzheimer neurofibrillary tangles. Tangles and their constituent PHF contain epitopes derived from or cross-reactive with both neurofilaments and tau proteins. These same structures are labelled with anti-PHF antibodies. A component of the anti-PHF serum is against tau proteins. We conclude that PHF are at least in part derived from an abnormal neuronal cytoskeleton.

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