par Imielinski, M;Baldassano, RN;Griffiths, Anne;Russell, RK;Annese, V;Dubinsky, M;Kugathasan, S;Bradfield, JP;Walters, TD;Sleiman, P;Kim, CE;Muise, A;Wang, K;Glessner, JT;Saeed, S;Zhang, H;Frackelton, EC;Hou, C;Flory, JH;Otieno, G;Chiavacci, RM;Grundmeier, R;Castro, Massimo;Latiano, A;Dallapiccola, B;Stempak, J;Abrams, DJ;Taylor, K;McGovern, D;Western Regional Alliance for Pediatric IBD, G;Silber, I;Wrobel, A;Quiros, J Carl;International IBD Genetics Consortium, Sarah;Barrett, DL;Hansoul, Judy H;Nicolae, R H;Cho, J D;Duerr, S R;Rioux, M S;Brant, Kent D;Silverberg, MM;Taylor, A;Barmuda, T;Bitton, LW;Dassopoulos, T;Datta, Anne-Marie;Green, EO;Griffiths, MT;Kistner, Miguel;Murtha, J I;Regueiro, L Philip;Rotter, A H;Schumm, SR;Steinhart, RJ;Targan, C;Xavier, Cynthia;NIDDK IBD Genetics Consortium, Mark;Libioulle, Jacques;Sandor, Ivo;Lathrop, Simon;Belaiche, Debby;Gut, Myriam;Heath, Paul;Laukens, André;Mni, Diana;Rutgeerts, Denis;Van Gossum, JP 
;Zelenika, M;Franchimont, Séverine ;Hugot, Edouard;De Vos, ,;Vermeire, ,;Louis, LR;Belgian-French IBD Consortium, CA;Wellcome Trust Case Control Consortium, H;Cardon, Elaine R;Anderson, T;Drummond, NJ;Nimmo, CM;Ahmad, SA;Prescott, J;Onnie, J;Fisher, S;Marchini, R;Ghori, M;Bumpstead, P;Gwillam, J.;Tremelling, D;Delukas, Jack;Mansfeld, CG;Jewell, M;Satsangi, M.;Mathew, M J;Parkes, MB;Georges, GD;Daly, B;Heyman, J;Ferry, J;Kirschner, R;Lee, M;Essers, A;Grand, D;Stephens, J;Levine, Salvatore;Piccoli, DS;Van Limbergen, SL;Cucchiara, L;Monos, DC;Guthery, SF;Denson, Olivier;Wilson, ;Grant, ;Dewit,
Référence Nature genetics, 41, 12, page (1335-1340)
Publication Publié, 2009-12
;Zelenika, M;Franchimont, Séverine ;Hugot, Edouard;De Vos, ,;Vermeire, ,;Louis, LR;Belgian-French IBD Consortium, CA;Wellcome Trust Case Control Consortium, H;Cardon, Elaine R;Anderson, T;Drummond, NJ;Nimmo, CM;Ahmad, SA;Prescott, J;Onnie, J;Fisher, S;Marchini, R;Ghori, M;Bumpstead, P;Gwillam, J.;Tremelling, D;Delukas, Jack;Mansfeld, CG;Jewell, M;Satsangi, M.;Mathew, M J;Parkes, MB;Georges, GD;Daly, B;Heyman, J;Ferry, J;Kirschner, R;Lee, M;Essers, A;Grand, D;Stephens, J;Levine, Salvatore;Piccoli, DS;Van Limbergen, SL;Cucchiara, L;Monos, DC;Guthery, SF;Denson, Olivier;Wilson, ;Grant, ;Dewit, Référence Nature genetics, 41, 12, page (1335-1340)
Publication Publié, 2009-12
Article révisé par les pairs
| Résumé : | The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD. |
