Titre :
  • Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation.
Auteur : Van De Wiele, C Justin ; Vaughn, James G ; Blackburn, Michael R ; Ledent, Catherine ; Jacobson, Marlene A ; Jiang, Hong ; Thompson, Linda F
Informations sur la publication : The Journal of clinical investigation, 110, 3, (page 395-402)
Statut de publication : Publié, 2002-08
Sujet CREF : Sciences bio-médicales et agricoles
Mots-clés MeSH : Adenosine Deaminase -- metabolism
Adenosine Kinase -- antagonists & inhibitors
Adenosylhomocysteinase
Animals
CD4-Positive T-Lymphocytes -- cytology
CD8-Positive T-Lymphocytes -- cytology
Cell Differentiation
Cell Survival
Deoxyadenine Nucleotides -- metabolism
Deoxyadenosines -- pharmacology
Hydrolases -- antagonists & inhibitors
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Proto-Oncogene Proteins c-bcl-2 -- genetics
Receptor, Adenosine A2A
Receptor, Adenosine A2B
Receptor, Adenosine A3
Receptors, Antigen, T-Cell, alpha-beta -- genetics
Receptors, Antigen, T-Cell, alpha-beta -- physiology
Receptors, Purinergic P1 -- agonists
Receptors, Purinergic P1 -- antagonists & inhibitors
Receptors, Purinergic P1 -- genetics
Thymus Gland -- cytology
Note : Journal Article
Research Support, U.S. Gov't, P.H.S.
Langue :
  • Anglais
Identificateurs : urn:issn:0021-9738 
info:doi/10.1172/JCI15683
info:pmid/12163459
info:pmcid/PMC151094