Titre:
  • Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation.
Auteur:Pozdzik, Agnieszka; Salmon, Isabelle; Debelle, Frédéric; Decaestecker, Christine; Van den Branden, C; Verbeelen, Dirk; Deschodt Lanckman, Monique; Vanherweghem, Jean-Louis; Nortier, Joëlle
Informations sur la publication:Kidney international, 73, 5, page (595-607)
Statut de publication:Publié, 2008-03
Sujet CREF:Sciences bio-médicales et agricoles
Mots-clés:Apoptosis
Aristolochic acid nephropathy
Myofibroblast
Oxidative stress
Proximal tubular cell
Transforming growth factor-β
MeSH keywords:Animals
Apoptosis
Aristolochic Acids -- toxicity
Cell Proliferation
Chemokine CCL2 -- urine
Collagen -- analysis
Collagen -- metabolism
DNA Damage
DNA Repair
Epithelium -- drug effects
Epithelium -- pathology
Fibrosis
Ki-67 Antigen -- analysis
Kidney Diseases -- chemically induced
Kidney Diseases -- pathology
Kidney Tubules, Proximal -- chemistry
Kidney Tubules, Proximal -- drug effects
Kidney Tubules, Proximal -- pathology
Male
Mesoderm -- pathology
Mitochondria -- pathology
Mutagens -- toxicity
Oxidative Stress
Rats
Rats, Wistar
Receptor Protein-Tyrosine Kinases -- analysis
Note générale:Journal Article
Research Support, Non-U.S. Gov't
Langue:Anglais
Identificateurs:urn:issn:0085-2538
info:doi/10.1038/sj.ki.5002714
info:pii/5002714
info:scp/39349086390
info:pmid/18094681