Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.

Goriely, Stanislas; Cavoy, Rani; Goldman, Michel

doi:doi/10.1111/j.1398-9995.2009.02039.x

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Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.

par Goriely, Stanislas

;Cavoy, Rani

;Goldman, Michel

Référence Allergy, 64, 5, page (702-709)
Publication Publié, 2009-05

Article révisé par les pairs

Résumé :

Cytokines produced by antigen-presenting cells govern the fate of helper T-cell responses. Herein, we review the impact of interleukin (IL)-23 and IL-27 on the outcome of T-helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T-cell-mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL-12 family members.

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